DHEA Sulfate
HRT MEMBERS ONLY
INDICATIONS FOR USE
DHEA is used to treat adrenal insufficiency, improve sexual function, and enhance overall well-being. It is also utilized off-label for anti-aging purposes, improving bone density, and treating depression or fatigue in postmenopausal women.
ROUTE OF ADMINISTRATION
Oral tablets or capsules.
Creams or suppositories
FORMULATIONS AND PRICING
| Medication | Formulation | Price |
|---|---|---|
| DHEA SR Capsules | 10mg (#30 / #60 / #90) | $42 / $66 / $99 |
| DHEA / Pregnenolone Capsules | 50mg-50mg Capsules (#30/#60#90)) | $47 / $75 / $113 |
| DHEA / Testosterone Cream | 50mg-40mg/gm (30/60g) | $47 / $75 |
| DHEA / Estradiol Suppository | 25mg-1.25mg (#30/#60/#90) | $90 / $180 / $270 |
COMMON INITIAL DOSING REGIMENS
Initial doses range from 25–50 mg daily, taken in the morning to mimic natural DHEA production. Lower doses (10–25 mg) are often used for anti-aging purposes.
MECHANISM OF ACTION
DHEA serves as a precursor to androgens and estrogens, converting to testosterone or estradiol in peripheral tissues. It exerts mild androgenic and estrogenic effects, influencing mood, energy, and overall hormonal balance.
COMMON SIDE EFFECTS
Endocrine: Acne, oily skin, and hair thinning due to androgenic effects.
Metabolic: Mild weight gain or fluid retention.
Reproductive: Changes in menstrual cycle patterns in premenopausal women.
Rare: High doses may suppress endogenous hormone production or increase the risk of hormone-sensitive cancers.
CONTRAINDICATIONS
Absolute: Known hormone-sensitive cancers, such as breast or ovarian cancer.
Relative: Use with caution in women with PCOS, severe liver dysfunction, or significant androgen sensitivity.
MORE INFORMATION
FDA Safety Data Sheet not available.