Kisspeptin-10

HRT MEMBERS ONLY

INDICATIONS FOR USE

Kisspeptin-10 is used off-label to enhance ovarian function, regulate menstrual cycles, and manage infertility. It is also being explored for its role in improving sexual desire and hormonal balance in postmenopausal women.

ROUTE OF ADMINISTRATION

  • Subcutaneous injection

FORMULATIONS AND PRICING

FormulationPrice
5mg multi-dose vial (1mg/mL x 5mL)$135

COMMON INITIAL DOSING REGIMENS

  • A typical dose is 0.1–0.3 mg subcutaneously, administered 2–3 times weekly. Dosing may be adjusted based on clinical response and serum testosterone levels.

MECHANISM OF ACTION

  • Kisspeptin-10 is a potent stimulator of the hypothalamic-pituitary-gonadal axis. It binds to GPR54 (kisspeptin receptor), triggering the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus. This leads to increased secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary, ultimately boosting testosterone production in the testes.

COMMON SIDE EFFECTS

  • Endocrine: Potential fluctuations in estrogen levels, leading to mild bloating or breast tenderness.

  • General: Headache, fatigue, or mild dizziness.

  • Injection Site: Temporary discomfort or swelling at the injection site.

  • Rare: Overstimulation of the hypothalamic-pituitary axis may lead to mood changes or irritability.

CONTRAINDICATIONS

  • Absolute: Known hypersensitivity to kisspeptin-10 or its components.

  • Relative: Caution is advised in women with polycystic ovary syndrome (PCOS) or a history of hormone-sensitive cancers.

MORE INFORMATION

  • FDA Safety Data Sheet not available (experimental peptide therapy)