INDICATIONS FOR USE

MOTS-C is an experimental peptide investigated for its role in mitochondrial function, energy regulation, and metabolic health. It shows promise for age-related metabolic disorders, obesity, and type 2 diabetes.

ROUTE OF ADMINISTRATION

• Subcutaneous injection.

COMMON INITIAL DOSING REGIMENS

• Research protocols often involve 10–20 mg administered subcutaneously 2–3 times per week for several weeks, followed by rest periods.

• Suggested protocol: Inject 5mg (50 units via insulin syringe) SQ every 5 days for 20 days; may repeat once every 6 months

MECHANISM OF ACTION

• MOTS-C is encoded by mitochondrial DNA and regulates metabolic homeostasis by modulating AMPK and insulin sensitivity. It enhances mitochondrial function, promotes glucose uptake, and protects against metabolic stress.

COMMON SIDE EFFECTS

• Mild: Fatigue, headache, or injection site reactions.

• Rare: Potential mitochondrial overactivation leading to oxidative stress or tissue fatigue.

CONTRAINDICATIONS

• Absolute: Hypersensitivity to MOTS-C or its excipients.

• Relative: Use cautiously in individuals with mitochondrial disorders, as overactivation may exacerbate underlying dysfunction.

MORE INFORMATION

• FDA Safety Data Sheet not available (experimental peptide).

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• Kal S. Mitochondrial-derived peptides: Antidiabetic functions and evolutionary perspectives. Peptides. 2024 [PubMed Link]

• Zhou Q. The correlation between mitochondrial derived peptide (MDP) and metabolic states: a systematic review and meta-analysis. Diabetol Metab Syndr. 2024 [PubMed Link]

• Kong BS. Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases. Diabetes Metab J. 2023 [PubMed Link]

• Mohtashami Z. MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases. Int J Mol Sci. 2022 [PubMed Link]

• Rochette L. Mitochondrial-derived peptides: New markers for cardiometabolic dysfunction. Arch Cardiovasc Dis. 2022 [PubMed Link]

• Wan W. Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging. J Transl Med. 2023 [PubMed Link]

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