NAD+
PEPTIDES+ MEMBERS ONLY
INDICATIONS FOR USE
NAD+ supplementation is primarily investigated in anti-aging medicine, metabolic health, and neuroprotection. It is proposed to enhance cellular energy, reduce age-related fatigue, and improve cognitive and mitochondrial function. NAD+ has also been studied for its role in managing neurodegenerative diseases and metabolic syndromes.
ROUTE OF ADMINISTRATION
Oral, sublingual, intravenous (IV), subcutaneous, or intranasal.
FORMULATIONS AND PRICING
| Formulation | Price |
|---|---|
| 300mg/mL nasal spray (30mg/spray) (15mL) | $145 |
COMMON INITIAL DOSING REGIMENS
Oral/Sublingual: 300–600 mg daily.
Intravenous: 500–1,000 mg over 1–2 hours, administered weekly or bi-weekly in clinical protocols.
Intranasal: Doses vary, often using specialized nasal sprays delivering 50–100 mg daily.
MECHANISM OF ACTION
NAD+ (nicotinamide adenine dinucleotide) is a critical coenzyme involved in redox reactions, mitochondrial function, and cellular repair mechanisms. It acts as a substrate for sirtuins and poly(ADP-ribose) polymerases (PARPs), regulating DNA repair, gene expression, and cellular stress responses. By boosting NAD+ levels, cellular metabolism, energy production, and resilience to oxidative damage are enhanced.
COMMON SIDE EFFECTS
Mild: Nausea, flushing, or lightheadedness, particularly with intravenous administration.
Metabolic: Fatigue or headache during initial use.
Injection or IV-related: Pain at the infusion site or localized swelling.
Rare: Hypersensitivity reactions, although infrequent, may include rash or mild anaphylaxis.
CONTRAINDICATIONS
Absolute: Hypersensitivity to NAD+ or its derivatives.
Relative: Use cautiously in patients with severe systemic illnesses, liver or kidney disease, or a history of allergic reactions to supplements.
DISCLAIMER
Although NAD+ is widely available as a supplement, intravenous administration is not FDA-approved for any specific indications.
MORE INFORMATION
FDA Safety Data Sheet not available.